化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyl piperazine-1-carboxylate → [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | Cyclopropanesulfonyl chloride | HCID 2760919 | — |
| 反応物 | 1-(Cyclopropylsulfonyl)piperazine | HCID 45496790 | — |
| 反応物 | 6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloride | HCID 67017930 | — |
| 生成物 | [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone | HCID 68566781 | 62% |
反応手順
The title compound was synthesized in analogy to example 1, from 6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate a) and cyclopropylsulfonyl-piperazine (prepared in analogy to International Patent Application Publ. No. WO 2003/064413 by using cyclopropylsulfonyl chloride and tert-butyl 1-piperazinecarboxylate) to afford the title compound as a light-yellow solid (62%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07507736B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-2200d6b7e9f94cecbba6c389b32d518b |
| 出典メモ | uspto-grants-2009_03 |