(Isocyanatomethylene)dibenzene → 1-Benzhydryl-3-(1-benzhydryl-2-oxo-pyrrolidin-3-yl)-urea

HRID 1786559

反応式

HRID 1786559 の反応式
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:3]1=[O:20].[C:21]1([CH:27]([N:34]=[C:35]=[O:36])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(Cl)Cl>[CH:27]([NH:34][C:35]([NH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:3]1=[O:20])=[O:36])([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

4

反応物 2

HCID 4250935(Isocyanatomethylene)dibenzeneHCID 575975623-Amino-1-benzhydryl-pyrrolidin-2-one

生成物 1

HCID 575975821-Benzhydryl-3-(1-benzhydryl-2-oxo-pyrrolidin-3-yl)-urea収率 65%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-amino-1-benzhydryl-pyrrolidin-2-one (42) (0.2 g, 0.75 mmol) in dry CH2Cl2 (15 ml) was added diphenylmethyl isocyanate (0.17 mg, 0.82 mmol) dropwise under nitrogen. The resulting mixture was stirred at room temperature for two days followed by refluxing for 5 hours. Removal of solvent under reduced pressure followed by column chromatography using hexane: ethyl acetate (2:1) gave the desired product in 65% yield.

後処理

  1. temperatureby refluxing for 5 hours
  2. customRemoval of solvent under reduced pressure

出典と根拠

ORDレコード
ord-90252da0f3144d0e85fb42da01f4d4d5
出典データセット
uspto-grants-2009_03
特許番号
US07507760B2

関連ノート

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