2-Amino-4-methylthiazole → HCID 16117059、化合物

反応式

Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.O.[CH3:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][N:17]=1.[NH2:25][C:26]1[S:27][CH:28]=[C:29]([CH3:31])[N:30]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:25][C:26]3[S:27][CH:28]=[C:29]([CH3:31])[N:30]=3)[N:3]=[CH:4][C:5]=2[C:19]2[CH:18]=[N:17][C:16]([CH3:15])=[CH:21][CH:20]=2)[N:10]=1

参加物

反応物 3

HCID 741432-Amino-4-methylthiazole

HCID 467390152-Picoline-5-boronic acid hydrate

HCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

生成物 1

HCID 16117059HCID 16117059、化合物

実験手順

The title compound, MS: m/e=348.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 2-methylpyridine-5-boronic acid hydrate and 2-amino-4-methylthiazole.

出典と根拠

ORDレコード: ord-8993cc82e4144605b5916d2099387376
出典データセット: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07511055B2

反応ノート

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