Acetic Acid → 6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
反応式
[CH2:1]([NH:6][C:7]([NH2:9])=[S:8])[CH2:2][CH2:3][CH2:4][CH3:5].[C:10]([CH2:12][C:13](OCC)=[O:14])#[N:11].[O-]CC.[Na+].C(O)(=O)C>C(O)C.O>[NH2:11][C:10]1[N:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:7](=[S:8])[NH:9][C:13](=[O:14])[CH:12]=1参加物
7
反応条件
- 温度
- 75 °C
実験手順
N-Pentylthiourea (10.0 g, 0.068 mol) was mixed with ethyl cyanoacetate (9.3 g, 0.082 mol) and sodium ethoxide (6.4 g, 0.094 mol) in ethanol (60 mL). The mixture was stirred at 75° C. overnight. After cooling, a solution of 10% acetic acid in water (150 mL) was added. The solid formed was collected by filtration and washed with water to afford the desired product (9.5 g, 65% yield). LCMS calculated for C9H16N3OS: (M+H) 214.1; found 214.1.
後処理
- temperatureAfter cooling
- customThe solid formed
- filtrationwas collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-a6e1d9166c2041abaaf04aa0e2d0a800
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07511050B2
反応ノート
読み込み中…