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Sodium hydride → Tert-butyl {3-[3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazol-1-yl]-1,1-dimethyl-propyl}-carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-(4-Fluoro-phenyl)-5-methyl-[1,2,4]triazole | HCID 43166756 | — |
| 反応物 | tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate | HCID 57429079 | — |
| 触媒 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 溶媒 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 生成物 | Tert-butyl {3-[3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazol-1-yl]-1,1-dimethyl-propyl}-carbamate | HCID 66886384 | — |
反応手順
5.88 g (33 mmol) of 3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazole are dissolved in 40 mL DMPU and reacted with 11.04 g (50 mmol) of tert.butyl (3-chloro-1,1-dimethyl-propyl)-carbamate, 1.59 g (40 mmol, 60%) of sodium hydride and 2.21 g (6 mmol) of tetrabutylammonium iodide in the manner described in P-1-c).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07511067B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-b2cc11185257469d8d38bfba1120cb56 |
| 出典メモ | uspto-grants-2009_03 |