化工社化工社 化学情報印刷レポート · 研究参考用
2-Ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid → Acetyl-5-aminosalicylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid | HCID 22341901 | — |
| 溶媒 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 生成物 | Acetyl-5-aminosalicylic acid | HCID 13140652 | 97.4% |
反応手順
The mixture of 2-ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid (1.01 g, 3.42 mmole) in TFA/CH2Cl2 (20.0 ml. 1:1 v/v) was stirred for 30 min at room temperature. After the reaction mixture was concentrated, the residue was dissolved in ether. The resulting residue was recrystallized from ethyl acetate/hexane to give 0.65 g (97% yield) of 2-ethanoyloxy-5-aminobenzoic acid as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07511074B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-f99c4245f5024eafbed92d5ba276e740 |
| 出典メモ | uspto-grants-2009_03 |