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Sodium Hydroxide → 4-(Piperidine-1-sulfonyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-(4-(1-Piperidinylsulfonyl)phenyl)acetamide | HCID 79780 | — |
| 反応物 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 4-(Piperidine-1-sulfonyl)aniline | HCID 236648 | 70.62% |
反応手順
N-[4-(Acetylamino)phenylsulfonyl]piperidine (Example 5) was heated at 100° C. in 20% hydrochloric acid (5 mL) for one hour (TLC ethyl acetate/dichloromethane 8:2). The solution is neutralized at 0° C. with NaOH. The precipitate that forms is filtered and recrystallized from methanol/diethyl ether to afford the desired N-[4-(amino)phenylsulfonyl]piperidine. 70.62% yield; white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07511133B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-72f5b3bac1774de1a6a19a42599f80db |
| 出典メモ | uspto-grants-2009_03 |