Benzyl Bromide → 1-(3-(Phenylmethoxy)phenyl)ethan-1-one

HRID 17882

反応式

HRID 17882 の反応式
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([OH:10])[CH:9]=1)=[O:3].C(=O)([O-])[O-].[K+].[K+].[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CC(C)=O>[CH2:17]([O:10][C:8]1[CH:9]=[C:4]([C:2](=[O:3])[CH3:1])[CH:5]=[CH:6][CH:7]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 84873-HydroxyacetophenoneHCID 11430Potassium Carbonate

生成物 1

HCID 986891-(3-(Phenylmethoxy)phenyl)ethan-1-one収率 98%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

3-Hydroxyacetophenone (136.15 g, 1 mol), potassium carbonate (414.63 g, 2 mol), KI (33.2 g, 0.2 mol), and benzyl bromide (171.04 g, 1 mol) were dissolved in acetone and the reaction mixture was refluxed while stirring for 24 hours, followed by washing with brine. The reaction mixture was extracted with ethyl acetate, the extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3) to obtain 1-(3-benzyloxyphenyl)ethanone (221.8 g, yield 98%) in an oil state.

後処理

  1. temperaturethe reaction mixture was refluxed
  2. washby washing with brine
  3. extractionThe reaction mixture was extracted with ethyl acetate
  4. dry with materialthe extract was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated
  6. customthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3)

出典と根拠

ORDレコード
ord-a937d91372ab4537b5a282709eb27a35
出典データセット
uspto-grants-2010_06
特許番号
US07741323B2

関連ノート

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