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Potassium hydroxide ethanol → 2-[2-Hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-quinoline-6-carboxylic Acid

HRID 1788413
ノート
印刷プレビュー

反応式

HRID 1788413 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[C:15](=O)[CH3:16].C[O:19][C:20](=[O:30])[C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[C:23]([CH:28]=O)[CH:22]=1.[OH-].[K+].C(O)C>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[C:15]1[CH:16]=[CH:28][C:23]2[C:24](=[CH:25][CH:26]=[C:21]([C:20]([OH:30])=[O:19])[CH:22]=2)[N:27]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 21946426Potassium hydroxide ethanolHCID 46911801Methyl 4-amino-3-formylbenzoateHCID 576031221-[2-Hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-ethanone

生成物 1

HCID 1360964502-[2-Hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-quinoline-6-carboxylic Acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Compound 18 (410 mg, 1.75 mmol) and Compound 7 (315 mg, 1.75 mmol) were dissolved in 30 mL of ethanol, 2.45 mL of a 10% KOH/ethanol solution was added and the mixture was refluxed overnight under argon. The ethanol was evaporated, the residue dissolved in water, and acidified with 3 mL of 1M HCl. The formed gel was solidified by addition of 30 mL of ethyl acetate and 30 mL of a saturated NaCl solution. The solid was filtered, awashed with water, and dried. Yield 302 mg (48%) Compound 19.

後処理

  1. temperaturethe mixture was refluxed overnight under argon
  2. customThe ethanol was evaporated
  3. dissolutionthe residue dissolved in water
  4. additionThe formed gel was solidified by addition of 30 mL of ethyl acetate and 30 mL of a saturated NaCl solution
  5. filtrationThe solid was filtered
  6. customdried

出典と根拠

ORDレコード
ord-a50cb176a218444796fa053ada1da08f
出典データセット
uspto-grants-2009_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07511145B2

反応ノート

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