Isatoic Anhydride → 2-amino-N-(3-imidazol-1-ylpropyl)benzamide

HRID 1788681ノート

反応式

HRID 1788681 の反応式
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[NH:13]1[CH:17]=[CH:16][N:15]=[C:14]1CCCN>C1(C)C=CC=CC=1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:6][CH2:7][CH2:1][CH2:11][N:15]1[CH:16]=[CH:17][N:13]=[CH:14]1)=[O:4]

参加物

4

反応物 2

HCID 8359Isatoic AnhydrideHCID 132907973-(1H-Imidazol-2-yl)propan-1-amine

生成物 1

HCID 27983352-amino-N-(3-imidazol-1-ylpropyl)benzamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
90 °C

実験手順

A mixture of 2.93 g of isatoic anhydride, 2.50 g of 1H-imidazole-propanamine and 30 ml of toluene was heated at 90° C. for 45 minutes and cooled. The toluene layer was decanted and the residue was dissolved in methylene chloride, washed with dilute sodium hydroxide solution, water and dried over magnesium sulfate. The organic layer was concentrated to obtain the desired product, mp 107°-110° C.

後処理

  1. temperaturecooled
  2. customThe toluene layer was decanted
  3. dissolutionthe residue was dissolved in methylene chloride
  4. washwashed with dilute sodium hydroxide solution, water
  5. dry with materialdried over magnesium sulfate
  6. concentrationThe organic layer was concentrated

出典と根拠

ORDレコード
ord-fc25cc5cc9dc4f369eadfd7bf10dd010
出典データセット
uspto-grants-1987_08
特許番号
US04684654

反応ノート

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