Di-tert-butyl glutamate hydrochloride → di-tert-butyl N-(4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoyl)-L-glutamate

HRID 1788711

反応式

HRID 1788711 の反応式
Cl.[NH2:2][C@H:3]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:4][CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[NH2:20][C:21]1[N:22]=[C:23]([NH2:42])[C:24]2[CH:30]=[C:29]([CH:31]=[CH:32][C:33]3[CH:38]=[CH:37][C:36]([C:39](O)=[O:40])=[CH:35][CH:34]=3)[CH:28]=[N:27][C:25]=2[N:26]=1>>[NH2:20][C:21]1[N:22]=[C:23]([NH2:42])[C:24]2[CH:30]=[C:29]([CH:31]=[CH:32][C:33]3[CH:38]=[CH:37][C:36]([C:39]([NH:2][C@H:3]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:4][CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:10])[CH3:11])=[O:7])=[O:40])=[CH:35][CH:34]=3)[CH:28]=[N:27][C:25]=2[N:26]=1

参加物

3

反応物 2

HCID 208636Di-tert-butyl glutamate hydrochlorideHCID 541209062,4-Diamino-6-[2-(4-carboxyphenyl)ethenyl]pyrido[2,3-d]pyrimidine

生成物 1

HCID 54172898di-tert-butyl N-(4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoyl)-L-glutamate

実験手順

Alternatively, 2.2 g (0.0074 mol) of di-tert-butyl L-glutamate hydrochloride were allowed to react with 1.5 g (0.0049 mol) of 2,4-diamino-6-[2-(4-carboxyphenyl)ethenyl]pyrido[2,3-d]pyrimidine, to yield di-tert-butyl N-(4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoyl)-L-glutamate in a yield of 1.3 g (48%), mp >300° C. NMR (CDCl3 /CD3OD) delta 1.47, 1.52 (2s, 18H), 2.0-2.6 (m, 4H), 4.5-7.0 (m, 1H), 6.8 (br, s, 2H), 7.35, 7.78 (AB q, 4H, J=9 Hz), 8.38 (s, 1H), 8.5 (s, 1H); IR (Nujol) 3350, 3180, 1725, 1640, 1605 cm-1. MS: Calc'd.: for C29H36N6O5 : 548. Found: m/e 548, 446, 290.

出典と根拠

ORDレコード
ord-9a8146047b3a4bd2b9d6f283d20589c9
出典データセット
uspto-grants-1987_08
特許番号
US04684653

関連ノート

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