関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Methanesulfonic Acid | HCID 6395 | — |
| 反応物 | 2-Amino-4,6-dimethyl pyrimidine | HCID 13021 | — |
| 反応物 | m-Toluenesulfonic acid | HCID 105362 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4,6-Dimethyl-2-(4-tolylsulfonylmethylamino)pyrimidine | HCID 23043221 | — |
反応手順
12.7 g (0.1 mole) of 2-amino-4,6-dimethylpyrimidine are suspended in 200 ml of water and then 9.7 g (0.1 mole) of methanesulfonic acid are stirred in to form a solution. To the stirred solution are added, in succession, 18.22 g (0.1 mole) of toluene-3-sulfonic acid, sodium salt, and 9.4 g (0.11 mole) of aqueous 35% formaldehyde. The mixture is stirred for 2 hours at room temperature and for another 30 minutes at 90° C. The colourless precipitate is filtered with suction after cooling and dried. Melting point: 191°-194° C. Yield: 25 g (86% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04685961 |
|---|
| 出典データセット | uspto-grants-1987_08 |
|---|
| ORD ID | ord-9ea8c5f23c574b2e8a2a3b12fa410e55 |
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| 出典メモ | uspto-grants-1987_08 |
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