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HRID 1788907作成日：2026年10月26日
1-Piperazinecarboxylic acid, ethyl ester → 4-(1,4-Dihydro-3-methyl-1, 4-dioxo-2-naphthalenyl)-1-piperazinecarboxylic acid, ethyl ester
https://huagongshe.com/reaction/1788907
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| 反応物 | 2,3-Epoxy-2-methyl-1,4-naphthoquinone | HCID 85845 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(1,4-Dihydro-3-methyl-1, 4-dioxo-2-naphthalenyl)-1-piperazinecarboxylic acid, ethyl ester | HCID 14278765 | 30.5% |
反応手順
A mixture of 1.88 g of 2,3-epoxy-3-methyl-1,4-naphthoquinone, 3.16 g of piperazinecarboxylic acid, ethyl ester and 100 ml of absolute ethanol was stirred for 12 hours at 50° C. The solvent was then removed and the remainder filtered through a one inch plug of silica gel and eluted with chloroform. The eluate was evaporated, giving 1 g of the desired product as a viscous red oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04686220 |
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| 出典データセット | uspto-grants-1987_08 |
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| ORD ID | ord-bd93f5c31e3a4d1182f4de13828044bc |
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| 出典メモ | uspto-grants-1987_08 |
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