6-Fluoronicotinic Acid → 1-(6-Fluoropyridin-3-yl)ethan-1-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][N:3]=1.[CH3:11][Li]>CCOCC>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[N:3][CH:4]=1)(=[O:10])[CH3:11]参加物
4
実験手順
To suspension of 20 gm. (]42 mmoles) of 2-fluoro-5-pyridinecarboxylic acid (J.Am. Chem. Soc., 71, 1125 (1949)) in 750 ml. of ether, stirred and cooled in ice, was added 225 ml. of 1.6 M methyl lithium (360 mmoles) in ether over 1 hr. The reaction was stirred for an additional 2 hr., then 300 ml. of ice water was added. The aqueous layer was washed with 2×100 ml. fresh ether, acidified and extracted with ether to give 5.0 gm. (25%) of unreacted starting acid.
後処理
- additionTo suspension of 20 gm
- temperaturecooled in ice
- additionwas added 225 ml
- washThe aqueous layer was washed with 2×100 ml
- extractionextracted with ether
- customto give 5.0 gm
出典と根拠
- ORDレコード
- ord-8ec6bc0ba583456dba19b4ce1259fcc1
- 出典データセット
- uspto-grants-1987_08
- 特許番号
- US04686222
反応ノート
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