Isoamyl Nitrite → 7-Chloro-2-methyl-3-nitrosoimidazo[2,1-a]isoquinoline
反応式
[N:1](OCCC(C)C)=[O:2].[Cl:9][C:10]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:11]=1[CH:12]=[CH:13][N:14]1[CH:22]=[C:21]([CH3:23])[N:20]=[C:15]12>O1CCOCC1>[Cl:9][C:10]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:11]=1[CH:12]=[CH:13][N:14]1[C:22]([N:1]=[O:2])=[C:21]([CH3:23])[N:20]=[C:15]12参加物
4
実験手順
Isoamyl nitrite (140 g) was added to a suspension of 7-chloro-2-methylimidazo[2,1-a]isoquinoline (17.1 g) in dioxane (170 ml) at 50° C. and the mixture was refluxed for 15 minutes. After being cooled, the resulting precipitate was collected by filtration, washed successively with dioxane and diethyl ether and dried in a desiccator to give 7-chloro-2-methyl-3-nitrosoimidazo[2,1-a]isoquinoline (7.7 g).
後処理
- temperaturethe mixture was refluxed for 15 minutes
- temperatureAfter being cooled
- filtrationthe resulting precipitate was collected by filtration
- washwashed successively with dioxane and diethyl ether
- customdried in a desiccator
出典と根拠
- ORDレコード
- ord-bad33391a14d457ea99c0d986f93938b
- 出典データセット
- uspto-grants-1987_08
- 特許番号
- US04686227
反応ノート
読み込み中…