化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl 2-nitro-4-benzoylphenylmalonate | HCID 13408230 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Nitro-4-benzoylphenylacetic acid | HCID 13770536 | 95% |
反応手順
A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04686224 |
| 出典データセット | uspto-grants-1987_08 |
| ORD ID | ord-abaea9c2d3f2432c870e6577b3d1cda8 |
| 出典メモ | uspto-grants-1987_08 |