Tetrafluoro-m-phenylenediamine dihydrochloride → 5-difluoromethoxy-2-[(4-methoxy-3-methyl-2-pyridyl)methylthio]-4,6-dimethyl-1H-benzimidazole

HRID 1789040ノート

反応式

HRID 1789040 の反応式
[F:1][CH:2]([F:16])[O:3][C:4]1[C:13]([CH3:14])=[CH:12][C:7]2[NH:8][C:9]([SH:11])=[N:10][C:6]=2[C:5]=1[CH3:15].Cl.Cl[CH2:19][C:20]1[C:25]([CH3:26])=[C:24]([O:27][CH3:28])[CH:23]=[CH:22][N:21]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>CC(O)C>[F:16][CH:2]([F:1])[O:3][C:4]1[C:13]([CH3:14])=[CH:12][C:7]2[NH:8][C:9]([S:11][CH2:19][C:20]3[C:25]([CH3:26])=[C:24]([O:27][CH3:28])[CH:23]=[CH:22][N:21]=3)=[N:10][C:6]=2[C:5]=1[CH3:15]

参加物

5

反応物 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 115139822-(Chloromethyl)-4-methoxy-3-methylpyridine--hydrogen chloride (1/1)HCID 178422367HCID 178422367、化合物

生成物 1

HCID 201895435-difluoromethoxy-2-[(4-methoxy-3-methyl-2-pyridyl)methylthio]-4,6-dimethyl-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

2.0 g of 5-difluoromethoxy-4,6-dimethyl-1H-benzimidazole-2-thiol and 1.72 g of 2-chloromethyl-4-methoxy-3-methylpyridine hydrochloride are heated in 30 ml of 2-propanol for 4 h to the boil. This gives 3.6 g of the dihydrochloride of the title compound. This is dissolved in water and concentrated hydrochloric acid, the solution is clarified with activated charcoal, the product is precipitated with dilute sodium hydroxide solution and the precipitate is recrystallised from butanol. This gives 2.6 g (85%) of the title compound (m.p. 190°-191° C.).

出典と根拠

ORDレコード
ord-c5373432472a4323af3eae21f7fcb069
出典データセット
uspto-grants-1987_08
特許番号
US04686230

反応ノート

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