Hydrochloric Acid → 4-Acetamidonaphthalene-1-sulfonic acid

HRID 1789407

反応式

HRID 1789407 の反応式
[C:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].N1C=CC=CC=1.Cl>O>[C:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([S:15]([OH:18])(=[O:16])=[O:17])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 13306497pyridine N-acetyl-1-aminonaphthalene-4-sulphonate

生成物 1

HCID 4169954-Acetamidonaphthalene-1-sulfonic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

15 g (0.04 mole) of pyridine N-acetyl-1-aminonaphthalene-4-sulphonate is dissolved in the minimum amount of water in an Erlenmeyer flask. This solution is conveniently cooled and is acidified with concentrated hydrochloric acid, following which the precipitate formed is collected in a filter to give N-acetyl-1-amino-4-naphthalenesulphonic acid, which is then filtered, washed and dried, and suspended in water. An aqueous solution of the stoichiometric amount of tranexamic acid (AMCHA) is then added, and the mixture is stirred for 15 minutes at ambient temperature and evaporated to dryness. The residue obtained is recrystallized in absolute alcohol, 14.1 g (Yield 76.6%) of AMCHA N-acetyl-1-aminonaphthalene-4-sulphonate finally being obtained, whose m.p. is 214°-215° C. and whose IR spectrum (KBr) has the following bands: 1,670; 1,650; 1,530; 1,510; 1,370; 1,320; 1,200; 1,040; 750; 670; 640.

後処理

  1. temperatureThis solution is conveniently cooled
  2. customformed
  3. customis collected in
  4. filtrationa filter

出典と根拠

ORDレコード
ord-c6d541891e04442aabb122c5d2326b45
出典データセット
uspto-grants-1987_08
特許番号
US04689346

関連ノート

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