Ammonia → 1-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride hydrate

HRID 1789420ノート

反応式

HRID 1789420 の反応式
C([O:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[C:16]([Cl:25])[C:15]=2[N:14]=[CH:13]1)(=[O:8])C1C=CC=CC=1.[NH3:26]>CO.Cl>[OH2:8].[ClH:25].[OH:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[C:16]([NH2:26])[C:15]=2[N:14]=[CH:13]1

参加物

5

反応物 2

HCID 222AmmoniaHCID 139584251-(2-benzoyloxyethyl)-4-chloro-1H-imidazo[4,5-c]quinoline

生成物 1

HCID 139828911-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride hydrate

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A mixture of 1.3 g (0.0037 mole) of 1-(2-benzoyloxyethyl)-4-chloro-1H-imidazo[4,5-c]quinoline (from Example 117) in 60 ml of methanol was saturated with about 10g of ammonia gas. The mixture was heated at 150° C. in a steel bomb for ten hours. The mixture was evaporated, and the residue was slurried in diethyl ether and filtered. The solid obtained was slurried in methanolic hydrochloric acid to provide off-white solid 1-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride hydrate, m.p. >250° C. Analysis: Calculated for C12H12N4O·HCl·1.25H2O: C, 50.2; % H, 5.4; % N, 19.5; Found: % C, 50.2; % H, 5.2; % N, 19.1.

後処理

  1. customThe mixture was evaporated
  2. filtrationfiltered
  3. customThe solid obtained

出典と根拠

ORDレコード
ord-d55cf3cb02ba41bab50cae8993ff9059
出典データセット
uspto-grants-1987_08
特許番号
US04689338

反応ノート

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