1-(4-Chlorophenyl)-2-butyn-1-ol → (Z)-1-(4-chlorophenyl)-2-buten-1-ol

HRID 1789457

反応式

HRID 1789457 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[C:9]#[C:10][CH3:11])=[CH:4][CH:3]=1>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])/[CH:9]=[CH:10]\[CH3:11])=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 201883391-(4-Chlorophenyl)-2-butyn-1-ol

生成物 1

HCID 67901371(Z)-1-(4-chlorophenyl)-2-buten-1-ol

試薬・触媒・溶媒 1

HCID 131709914Lindlars catalyst触媒

実験手順

Under nitrogen, hydrogenate a mixture of 10 g (0.055 mole) of 1-(4-chlorophenyl)-2-butyn-1-ol and 0.6 g Lindlar catalyst. Following the reaction via NMR the reaction is complete in about two days. The hydrogenation is stopped and the reaction stirred under N2 at room temperature overnight. Filter off the catalysts, wash with methylene chloride combine the filtrate and evaporate to yield the title compound.

後処理

  1. customthe reaction via NMR the reaction
  2. filtrationFilter off the catalysts
  3. washwash with methylene chloride
  4. customevaporate

出典と根拠

ORDレコード
ord-93abc6b367ac4c85828867dcc8b49366
出典データセット
uspto-grants-1987_08
特許番号
US04689341

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