Water → 1-Bromo-4-ethoxy-2-(trifluoromethyl)benzene

HRID 1789630ノート

反応式

HRID 1789630 の反応式
[Br:1]Br.[CH2:3]([O:5][C:6]1[CH:7]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:10][CH:11]=1)[CH3:4].O>CCOCC>[Br:1][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:3][CH3:4])=[CH:7][C:8]=1[C:12]([F:13])([F:14])[F:15]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 184153071-Ethoxy-3-(trifluoromethyl)benzene

生成物 1

HCID 220349931-Bromo-4-ethoxy-2-(trifluoromethyl)benzene収率 76.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

後処理

  1. extractionthe aqueous layer was extracted three times with ether
  2. washwashed with saturated aqueous sodium bicarbonate and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-e2b1c3cd2a7f482abbd02b5942d73d0c
出典データセット
uspto-grants-2006_07
特許番号
US07070838B2

反応ノート

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