Boron tribromide → 2-Trifluoromethylhydroquinone

HRID 1789633ノート

反応式

HRID 1789633 の反応式
B(Br)(Br)Br.C([O:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([C:15]([F:18])([F:17])[F:16])[CH:9]=1)C>ClCCl>[F:16][C:15]([F:17])([F:18])[C:10]1[CH:9]=[C:8]([OH:7])[CH:13]=[CH:12][C:11]=1[OH:14]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 220349974-Ethoxy-2-(trifluoromethyl)phenol

生成物 1

HCID 111166062-Trifluoromethylhydroquinone収率 63.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-78 °C

実験手順

Boron tribromide (11.8 g) was slowly added dropwise to dichloromethane (41 mL) cooled to −78° C., and then Compound (e) (6.47 g) dissolved in dichloromethane (60 mL) was slowly added dropwise at the same temperature and the mixture was stirred at room temperature for 2 hours. The reaction mixture was then poured into ice water and the aqueous layer was extracted with ether. The organic layers were combined, washed with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 3.53 g of Compound (g).

後処理

  1. additionwas slowly added dropwise at the same temperature
  2. extractionthe aqueous layer was extracted with ether
  3. washwashed with saturated aqueous sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-3eaf5a5c4504444dad2bbf538ca8f3b7
出典データセット
uspto-grants-2006_07
特許番号
US07070838B2

反応ノート

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