Cycloheptanone → N-Cycloheptylglycine

反応式

[C:1]1(=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C[O:10][C:11](=[O:14])[CH2:12][NH2:13]>>[CH:1]1([NH:13][CH2:12][C:11]([OH:14])=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

反応物 2

HCID 10400Cycloheptanone

HCID 69221Glycine methyl ester

生成物 1

HCID 21197386N-Cycloheptylglycine

実験手順

N-Cycloheptylglycine was synthesized by reductive amination of cycloheptanone with glycine methyl ester following the procedure described in Gera et al., Immunopharmacology. 33:174–177 (1996). The crude product was converted to the N-Boc derivative (mp, 89–90° C.).

出典と根拠

ORDレコード: ord-4d12ac80a56d479baf43142f1db2788d
出典データセット: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07071168B2

反応ノート

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