2-Acetylsulfanylmethyl-3-(2-amino-pyridin-4-yl)-propionic acid ethyl ester → 2-(2-Amino-pyridin4-ylmethyl)-3-mercapto-propionic acid

HRID 1789801ノート

反応式

HRID 1789801 の反応式
C([O:3][C:4](=[O:19])[CH:5]([CH2:14][S:15]C(=O)C)[CH2:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[CH:8]=1)C>Cl>[NH2:13][C:9]1[CH:8]=[C:7]([CH2:6][CH:5]([CH2:14][SH:15])[C:4]([OH:19])=[O:3])[CH:12]=[CH:11][N:10]=1

参加物

3

反応物 1

HCID 541499282-Acetylsulfanylmethyl-3-(2-amino-pyridin-4-yl)-propionic acid ethyl ester

生成物 1

HCID 101767122-(2-Amino-pyridin4-ylmethyl)-3-mercapto-propionic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-Acetylsulfanylmethyl-3-(2-amino-pyridin4-yl)-propionic acid ethyl ester (52 mg, 0.13 mmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 1 h. Concentration under reduced pressure gave the title compound as the hydrochloride salt (32 mg, 100%).

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux for 1 h
  3. concentrationConcentration under reduced pressure

出典と根拠

ORDレコード
ord-4bf3e9ebafb04352b1ad44652b3c3909
出典データセット
uspto-grants-2006_07
特許番号
US07071175B1

反応ノート

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