2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester → 3-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

HRID 1789824ノート

反応式

HRID 1789824 の反応式
C([O:3][C:4](=[O:21])[C:5]([CH2:16][S:17]C(=O)C)([CH3:15])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([NH2:14])=[C:11]([CH3:13])[CH:12]=1)C>Cl>[NH2:14][C:10]1[N:9]=[CH:8][C:7]([CH2:6][C:5]([CH2:16][SH:17])([CH3:15])[C:4]([OH:21])=[O:3])=[CH:12][C:11]=1[CH3:13]

参加物

3

反応物 1

HCID 572012572-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester

生成物 1

HCID 101986553-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (17 mg, 40 μmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 150 min. Concentration under reduced pressure gave the title compound as the hydrochloride salt (10.7 mg, 96%).

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux for 150 min
  3. concentrationConcentration under reduced pressure

出典と根拠

ORDレコード
ord-b962369971ea4d278e8a5ef08961e63a
出典データセット
uspto-grants-2006_07
特許番号
US07071175B1

反応ノート

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