Hydrochloric Acid → 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-butyric acid
反応式
Cl.C([O:4][C:5](=[O:21])[CH:6]([CH2:16][S:17]C(=O)C)[CH:7]([C:9]1[CH:10]=[N:11][C:12]([NH2:15])=[CH:13][CH:14]=1)[CH3:8])C>>[NH2:15][C:12]1[N:11]=[CH:10][C:9]([CH:7]([CH3:8])[CH:6]([CH2:16][SH:17])[C:5]([OH:21])=[O:4])=[CH:14][CH:13]=1参加物
3
実験手順
Conc. hydrochloric acid (4 mL) was added to 2-acetylsulfanylmethyl-3-(6amino-pyridin-3-yl)-butyric acid ethyl ester (104 mg, 0.253 mmol) under argon. The reaction was heated to reflux for 5 h and then concentrated under reduced pressure to give a diastereomeric mixture of the title compound (61 mg, 92%) as the hydrochloride salt.
後処理
- temperatureThe reaction was heated
- temperatureto reflux for 5 h
- concentrationconcentrated under reduced pressure
- customto give
出典と根拠
- ORDレコード
- ord-508daf97ba984034880e115a2676fc9f
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07071175B1
反応ノート
読み込み中…