2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester → 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid

HRID 1789915ノート

反応式

HRID 1789915 の反応式
C([O:3][C:4](=[O:32])[CH:5]([CH2:27][S:28]C(=O)C)[CH:6]([C:13]1[CH:14]=[N:15][C:16]([NH:19]C(OC(C)(C)C)=O)=[CH:17][CH:18]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C>Cl>[NH2:19][C:16]1[N:15]=[CH:14][C:13]([CH:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:5]([CH2:27][SH:28])[C:4]([OH:32])=[O:3])=[CH:18][CH:17]=1

参加物

3

反応物 1

HCID 539704052-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester

生成物 1

HCID 220361473-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl )-3-phenyl-propionic acid ethyl ester (58 mg, 0.125 mmol) was dissolved in conc. HCl (3.0 mL). The solution was heated to reflux for 130 min under argon. Concentration under reduced pressure gave the title compound as the hydrochloride salt (41 mg, 100%).

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux for 130 min under argon
  3. concentrationConcentration under reduced pressure

出典と根拠

ORDレコード
ord-17582d8f0b60422395c84343561351ad
出典データセット
uspto-grants-2006_07
特許番号
US07071175B1

反応ノート

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