Potassium Hydroxide → 2,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine

HRID 1789944ノート

反応式

HRID 1789944 の反応式
[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]#[N:11])=[C:6]([S:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=2[F:21])[N:5]=[C:4]([S:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=2[F:31])[N:3]=1.[OH-].[K+]>CO.ClCCl>[Cl:30][C:26]1[C:25]([F:31])=[C:24]([CH2:23][S:22][C:4]2[N:5]=[C:6]([S:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=3[F:21])[C:7]3[C:2](=[N:1][C:10]([NH2:11])=[CH:9][N:8]=3)[N:3]=2)[CH:29]=[CH:28][CH:27]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 22037040[[4-Amino-2,6-bis[[(3-chloro-2-fluorophenyl)methyl]thio]-5-pyrimidinyl]amino]acetonitrile

生成物 1

HCID 220370352,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of the product from example 13, step (b) (1.4 g) and potassium hydroxide (110 mg) in methanol (80 ml) and dichloromethane (120 ml) was stirred at room temperature for 24 hours. After evaporation in vacuo, the residue rendered the subtitled compound as a pale yellow solid (1.4 g).

後処理

  1. customAfter evaporation in vacuo

出典と根拠

ORDレコード
ord-8b0ef7003d124452b8d43d2ab90b786d
出典データセット
uspto-grants-2006_07
特許番号
US07071193B2

反応ノート

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