Hydrochloric Acid → HCID 69001190、化合物
反応式
Cl.[CH3:2][O:3][C:4](=[O:38])[C@@H:5]([NH:10][C:11]([N:13]1[CH2:19][CH:18]([OH:20])[C@@H:17]([NH:21][C:22](=[O:36])[C@@H:23]([NH:28]C(OC(C)(C)C)=O)[CH2:24][CH:25]([CH3:27])[CH3:26])[CH2:16][CH2:15][C@H:14]1[CH3:37])=[O:12])[CH2:6][CH:7]([CH3:9])[CH3:8]>O1CCOCC1.CO>[CH3:2][O:3][C:4](=[O:38])[C@@H:5]([NH:10][C:11]([N:13]1[CH2:19][CH:18]([OH:20])[C@@H:17]([NH:21][C:22](=[O:36])[C@@H:23]([NH2:28])[CH2:24][CH:25]([CH3:26])[CH3:27])[CH2:16][CH2:15][C@H:14]1[CH3:37])=[O:12])[CH2:6][CH:7]([CH3:9])[CH3:8]参加物
5
実験手順
4.0 M HCl in dioxane (8 ml) was added to a stirred solution (S)-2-({1-[(2R,5S)-5-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-2-methyl-6-hydroxy-azepan-1-yl]-methanoyl}-amino)-4-methyl-pentanoic acid methyl ester (490 mg, 0.93 mmol) in MeOH (8 ml). The reaction mixture was stirred for 2.5 h at RT, then was concentrated in vacuo by rotary evaporation and was used in the next reaction without further purification (430 mg).