4-Bromo-N-hydroxybenzimidamide → 2,5-Bis(4-cyanophenyl)furan

HRID 1790731ノート

反応式

HRID 1790731 の反応式
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6](=NO)[NH2:7])=[CH:4][CH:3]=1.[C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[O:21][CH:22]=[CH:23][CH:24]=2)=[CH:16][CH:15]=1)#[N:13]>C(#N)C1C=CC=CC=1>[C:12]([C:14]1[CH:15]=[CH:16][C:17]([C:20]2[O:21][C:22]([C:2]3[CH:11]=[CH:10][C:5]([C:6]#[N:7])=[CH:4][CH:3]=3)=[CH:23][CH:24]=2)=[CH:18][CH:19]=1)#[N:13]

参加物

4

反応物 2

HCID 27568384-Bromo-N-hydroxybenzimidamide2 回HCID 34195404-(2-furyl)benzonitrile

生成物 1

HCID 6229852,5-Bis(4-cyanophenyl)furan

試薬・触媒・溶媒 1

HCID 7505Benzonitrile溶媒

実験手順

in good yield. In contrast, under N-coupling conditions the benzamidoxime was converted to benzonitrile (Anbazhagan et al., (2002) Tetrahedron Lett. 43: 4221) and attempted Heck coupling of 4-bromobenzamidoxime with 2(4-cyanophenyl)furan yielded 2,5-bis(4-cyanophenyl)furan.

出典と根拠

ORDレコード
ord-23c53c47db3d41769913a28db1a35118
出典データセット
uspto-grants-2006_07
特許番号
US07071338B2

反応ノート

読み込み中…