Benzyl Bromide → Cromolyn

反応式

[Na].[Na].[C:3]([C:6]1[O:7][C:8]2[C:13]([C:14](=[O:16])[CH:15]=1)=[C:12]([O:17][CH2:18][CH:19]([OH:36])[CH2:20][O:21][C:22]1[CH:31]=[CH:30][CH:29]=[C:28]3[C:23]=1[C:24](=[O:35])[CH:25]=[C:26]([C:32]([OH:34])=[O:33])[O:27]3)[CH:11]=[CH:10][CH:9]=2)([OH:5])=[O:4].C(Br)C1C=CC=CC=1.C(=O)([O-])O.[Na+]>CN(C=O)C>[C:32]([C:26]1[O:27][C:28]2[C:23]([C:24](=[O:35])[CH:25]=1)=[C:22]([O:21][CH2:20][CH:19]([OH:36])[CH2:18][O:17][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]3[C:13]=1[C:14](=[O:16])[CH:15]=[C:6]([C:3]([OH:5])=[O:4])[O:7]3)[CH:31]=[CH:30][CH:29]=2)([OH:34])=[O:33]

参加物

実験手順

1,3-bis(2-carboxychromon-5-yloxy)-propan-2-ol disodium salt (2.5 g, 5.2 mmol), was suspended in DMF. To the suspension was added benzyl bromide (0.734 ml, 6.2 mmol) and the reaction was kept overnight under stirring. An additional portion of benzyl bromide (0.734 ml, 6.2 mmol) was added. After 24 hr, the reaction mixture was poured into sodium hydrogen carbonate aqueous solution and extracted dichloromethane. The organic phase was washed with water two times and evaporated to give the dibenzyl ester of 1,3-bis-(2-carboxychromon-5-yloxy)propan-2-ol (1.72 g).