[5-(2-morpholin-4-yl-ethoxy)-1H-indol-2-yl]-methanol → 5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde
反応式
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14]([CH2:19][OH:20])=[CH:13]3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>ClCCl.[O-2].[Mn+4].[O-2]>[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14]([CH:19]=[O:20])=[CH:13]3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1参加物
4
実験手順
Manganese (IV) oxide (3.2 g, 36 mmol) was added to [5-(2-morpholin-4-yl-ethoxy)-1H-indol-2-yl]-methanol (0.7 g) in dichloromethane (150 mL). The mixture was stirred at room temperature for 16 hours. The precipitate was filtered off and the filtrate was concentrated. The residue was recrystallized from ethyl acetate and hexane to give 0.18 g of 5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde.