Hydrochloric Acid → Methyl 4-(morpholin-4-yl)-3-oxobutanoate
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9](=[O:15])[CH2:10][C:11]([O:13][CH3:14])=[O:12].O.Cl>ClCCl>[N:1]1([CH2:8][C:9](=[O:15])[CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1参加物
6
実験手順
1.27 g (14.6 mmol) of morpholine are added to a solution of 1.0 g (6.64 mmol) of methyl 4-chloroacetoacetate in 10 ml of dichloromethane, and the mixture is stirred at room temperature for 4 hours. Water is then added and the mixture is neutralized with 2N hydrochloric acid. The organic phase is dried over sodium sulfate and concentrated, and the residue is chromatographed on silica gel with cyclohexane/ethyl acetate (10:1→4:1→1:1) as mobile phase.
後処理
- dry with materialThe organic phase is dried over sodium sulfate
- concentrationconcentrated
- customthe residue is chromatographed on silica gel with cyclohexane/ethyl acetate (10:1→4:1→1:1) as mobile phase
出典と根拠
- ORDレコード
- ord-66697104511a4a11a5a05a459f0b31cc
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07074784B2
反応ノート
読み込み中…