4-Piperidinecarboxamide → benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate

HRID 1791957ノート

反応式

HRID 1791957 の反応式
[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.C(N(CC)CC)C.C(Cl)(=O)O[O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[C:29](=O)([O-])[OH:30].[Na+]>ClCCl>[CH2:20]([O:19][C:29]([N:1]1[CH2:9][CH2:8][CH:4]([C:5](=[O:6])[NH2:7])[CH2:3][CH2:2]1)=[O:30])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

参加物

6

反応物 4

HCID 37724-PiperidinecarboxamideHCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 21874344HCID 21874344、化合物

生成物 1

HCID 2776131benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Isonipecotamide (19.4 g) and triethylamine (42 mL) were dissolved in dichloromethane (500 mL), and benzyloxy chlorocarbonate (24 mL) was added thereto under ice-cooling. The mixture was stirred at room temperature for 18 hr. The reaction mixture was added to saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with chloroform. The extract was dried and concentrated under reduced pressure to give 1-benzyloxycarbonyl-4-carbamoylpiperidine (33.3 g) as a white solid.

後処理

  1. temperatureunder ice-cooling
  2. extractionthe mixture was extracted with chloroform
  3. customThe extract was dried
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d863b73c392e4aa7ab2a5db34021dbe8
出典データセット
uspto-grants-2006_07
特許番号
US07074794B2

反応ノート

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