3-[7-Methoxy-3-(4-methoxyphenyl)thiochroman-4-yl]benzyl alcohol → 3-[7-Methoxy-3-(4-methoxyphenyl)thiochroman-4-yl]benzaldehyde
反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]([C:21]3[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=3)[CH2:24][OH:25])[CH:8]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[CH2:9][S:10]2)=[CH:5][CH:4]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]([C:21]3[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=3)[CH:24]=[O:25])[CH:8]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=3)[CH2:9][S:10]2)=[CH:5][CH:4]=1参加物
4
反応条件
- 温度
- 40 °C
実験手順
The mixture of 3-[7-methoxy-3-(4-methoxyphenyl)thiochroman-4-yl]benzyl alcohol (358 mg, 0.912 mmol) and manganese(IV) oxide (634 mg, 7.296 mmol) in methylene chloride (80 ml) was stirred at 40° C. for 3 h. When the reaction was completed, methylene chloride was added to the reaction mixture, which was then filtrated over silica gel and washed with several times with methylene chloride. The organic layer was concentrated under reduced pressure to give 360 mg (quant.) of the title compound as a white crystal.