2-(Tri-n-butylstannyl)thiophene → 6-Bromo-4-(2-thienyl)quinazoline

HRID 1792442ノート

反応式

HRID 1792442 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2Cl.C([Sn](CCCC)(CCCC)[C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)CCC>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:18]1[S:19][CH:20]=[CH:21][CH:22]=1

参加物

4

反応物 2

HCID 27793732-(Tri-n-butylstannyl)thiopheneHCID 167703106-Bromo-4-chloro-quinazoline

生成物 1

HCID 220314806-Bromo-4-(2-thienyl)quinazoline

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

0.6 g 6-bromo-4-chloroquinazoline was dissolved in 18 mL toluene, and 0.82 mL tri-n-butyl(2-thienyl)stannane and 0.14 g tetrakis (triphenylphosphine)palladium (0) were added thereto and stirred at 80° C. for 24 hours under nitrogen atmosphere. After the solvent was evaporated, the residue was purified by silica gel chromatography (hexane/ethyl acetate), to give 0.29 g of the title compound as yellow crystals.

後処理

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel chromatography (hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-4b79f5dff96f4fe7a29b5ace3d4445d4
出典データセット
uspto-grants-2006_07
特許番号
US07074801B1

反応ノート

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