HCID 22032234、化合物 → 6-Bromo-8-chloroimidazo[1,2-A]pyridine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([Cl:11])[C:5]2[N:6]([CH2:8][CH2:9][N:10]=2)[CH:7]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[C:4]([Cl:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1参加物
4
実験手順
2.08 g of 6-bromo-8-chloro-2,3-dihydroimidazo[1,2-a]pyridine was dissolved in 36 mL acetone, and together with 9.1 g of manganese dioxide, the mixture was heated for 9 hours under reflux. The reaction solution was cooled to room temperature, filtered through Celite and washed with ethyl acetate. The solvent was removed, and the resulting crude product was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give 1.27 g of the title compound (pale yellow crystals).
後処理
- temperatureunder reflux
- filtrationfiltered through Celite
- washwashed with ethyl acetate
- customThe solvent was removed
- customthe resulting crude product was purified by NH silica gel column chromatography (ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-841344a4b5f34e848713fd145538d083
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07074801B1
反応ノート
読み込み中…