Tributyltin Chloride → HCID 22031857、化合物

反応式

Br[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.[CH2:15]([Sn:19](Cl)([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:20][CH2:21][CH2:22][CH3:23])[CH2:16][CH2:17][CH3:18]>>[CH3:14][N:11]1[CH2:12][CH2:13][N:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Sn:19]([CH2:20][CH2:21][CH2:22][CH3:23])([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:15][CH2:16][CH2:17][CH3:18])[N:7]=2)[CH2:9][CH2:10]1

参加物

反応物 2

HCID 15096Tributyltin Chloride

HCID 193868331-(6-Bromopyridin-2-yl)-4-methylpiperazine

生成物 1

HCID 22031857HCID 22031857、化合物

実験手順

190 mg 1-methyl-4-(6-tributylstannyl-2-pyridyl)-piperazine obtained from 1-(6-bromo-2-pyridyl)-4-methyl piperazine and tributyltin chloride by the same method as in Production Method 46 was reacted in the same manner as in Example 21 with 129 mg 6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-3-iodoimidazo[1,2-a]pyridine obtained in Production Example 39, to give 91 mg of the title compound as a colorless amorphous.

出典と根拠

ORDレコード: ord-136669f5a3144fd993ca58fd135d8a87
出典データセット: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07074801B1

反応ノート

読み込み中…