Dimethylformamide → HCID 22024515、化合物

HRID 1793065ノート

反応式

HRID 1793065 の反応式
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1.P(Cl)(Cl)(Cl)=O.CN(C)[CH:20]=[O:21]>>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:20]=[O:21])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 120740798-Chloro-2-ethylimidazo[1,2-a]pyrazine

生成物 1

HCID 22024515HCID 22024515、化合物

反応条件

温度
90 °C

実験手順

8-Chloro-2-ethylimidazo[1,2-a]pyrazine (600 mg, 3.3 mmol) was dissolved in N,N-dimethylformamide (3.3 mL), phosphorus oxychloride (1.2 mL, 13.2 mmol) was added dropwise at room temperature, and the mixture was heated under stirring at 90° C. for 2 hours. After being allowed to cool, the reaction mixture was poured into ice and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and evaporated to give the title compound (472 mg) as white crystals.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto cool
  3. additionthe reaction mixture was poured into ice
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-e51d2344008247c5826386b93d8b5392
出典データセット
uspto-grants-2006_07
特許番号
US07078405B2

反応ノート

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