Phenyl-piperidin-4-yl-methanol → [1-(3-Amino-3-phenyl-propyl)-piperidin-4-yl]-phenyl-methanol

反応式

Br[CH2:2][CH2:3][CH:4]([NH:11]C(OC(C)(C)C)=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:19]1([CH:25]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[OH:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[NH2:11][CH:4]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[CH2:3][CH2:2][N:30]1[CH2:29][CH2:28][CH:27]([CH:25]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[OH:26])[CH2:32][CH2:31]1

参加物

反応物 2

HCID 339086Phenyl-piperidin-4-yl-methanol

HCID 22026034478538-78-2

生成物 1

HCID 22026074[1-(3-Amino-3-phenyl-propyl)-piperidin-4-yl]-phenyl-methanol

実験手順

The procedure given in Example 2 except for the formation of salts was followed using 3-bromo-1-(tert-butoxycarbonyl)amino-1-phenyl propane and phenyl-piperidin-4-yl-methanol as reactants, instead of d-1-bromo-2-(tert-butoxycarbonyl)amino-3-phenyl propane and hexamethyleneimine to give [1-(3-Amino-3-phenyl-propyl)-piperidin-4-yl]-phenyl-methanol.

出典と根拠

ORDレコード: ord-acd83b19b47d45b8a4f04bb5230bd5a2
出典データセット: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07078537B2

反応ノート

読み込み中…

参加物