(4-Fluorophenyl)(piperidin-4-yl)methanol → HCID 9924146、化合物

反応式

Br[CH2:2][CH2:3][CH:4]([NH:11]C(OC(C)(C)C)=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[OH:27])=[CH:22][CH:21]=1>>[NH2:11][CH:4]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[CH2:3][CH2:2][N:31]1[CH2:32][CH2:33][CH:28]([CH:26]([C:23]2[CH:22]=[CH:21][C:20]([F:19])=[CH:25][CH:24]=2)[OH:27])[CH2:29][CH2:30]1

参加物

反応物 2

HCID 4778266(4-Fluorophenyl)(piperidin-4-yl)methanol

HCID 22026034478538-78-2

生成物 1

HCID 9924146HCID 9924146、化合物

実験手順

The procedure given in Example 2 was followed using 3-bromo-1-(tert-butoxycarbonyl)amino-1-phenyl propane and (4-fluorophenyl)-piperidin-4-yl-methanol as reactants, instead of d-1-bromo-2-(tert-butoxycarbonyl)amino-3-phenyl propane and hexamethyleneimine to give [1-(3-Amino-3-phenyl-propyl)-piperidin-4-yl]-(4-fluoro-phenyl)-methanol.

出典と根拠

ORDレコード: ord-00b0281c50da4bacb5aa3150161bb91c
出典データセット: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07078537B2

反応ノート

読み込み中…

参加物