4,6-Dichloro-5-pyrimidinecarbaldehyde → 2-(4,6-Dichloro-pyrimidin-5-yl)-6-imidazol-1-yl-4-methyl-1H-benzimidazole

HRID 1793715ノート

反応式

HRID 1793715 の反応式
[N:1]1([C:6]2[CH:11]=[C:10]([NH2:12])[C:9]([NH2:13])=[C:8]([CH3:14])[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl:15][C:16]1[C:21]([CH:22]=O)=[C:20]([Cl:24])[N:19]=[CH:18][N:17]=1>CO>[Cl:15][C:16]1[C:21]([C:22]2[NH:12][C:10]3[CH:11]=[C:6]([N:1]4[CH:5]=[CH:4][N:3]=[CH:2]4)[CH:7]=[C:8]([CH3:14])[C:9]=3[N:13]=2)=[C:20]([Cl:24])[N:19]=[CH:18][N:17]=1

参加物

4

反応物 2

HCID 8196914,6-Dichloro-5-pyrimidinecarbaldehydeHCID 104199825-Imidazol-1-yl-3-methyl-benzene-1,2-diamine

生成物 1

HCID 220211832-(4,6-Dichloro-pyrimidin-5-yl)-6-imidazol-1-yl-4-methyl-1H-benzimidazole収率 55%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of 5-imidazol-1-yl-3-methyl-benzene-1,2-diamine (180 mg, 0.96 mmol) in methanol (4 mL) was added a solution of 4,6-dichloro-pyrimidine-5-carbaldehyde (183 mg, 0.96 mmol) in methanol (1 mL). The reaction mixture was stirred at room temperature for 14 h. After concentration, the residue was purified by flash column chromatography (5% methanol/CH2Cl2) to yield the title compound (180 mg, 55%). LCMS (M+H)+ m/z 344 (t=1.31 min.).

後処理

  1. concentrationAfter concentration
  2. customthe residue was purified by flash column chromatography (5% methanol/CH2Cl2)

出典と根拠

ORDレコード
ord-2fb724584d8e4136acef0b1feedd5538
出典データセット
uspto-grants-2006_07
特許番号
US07081454B2

反応ノート

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