Benzenemethanol, 4-(difluoromethoxy)-2,6-difluoro- → 2,6-Difluoro-4-difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

HRID 1794096

反応式

HRID 1794096 の反応式
[Cl:1][C:2]([N:4]1[C@H:9]([CH3:10])[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][C@@H:5]1[CH3:18])=[O:3].[F:19][C:20]1[CH:27]=[C:26]([O:28][CH:29]([F:31])[F:30])[CH:25]=[C:24]([F:32])[C:21]=1[CH2:22][OH:23]>>[ClH:1].[CH3:18][C@H:5]1[CH2:6][NH:7][CH2:8][C@@H:9]([CH3:10])[N:4]1[C:2]([O:23][CH2:22][C:21]1[C:20]([F:19])=[CH:27][C:26]([O:28][CH:29]([F:30])[F:31])=[CH:25][C:24]=1[F:32])=[O:3]

参加物

3

反応物 2

HCID 69140944Benzenemethanol, 4-(difluoromethoxy)-2,6-difluoro-HCID 86585999rel-1,1-Dimethylethyl (3R,5S)-4-(chlorocarbonyl)-3,5-dimethyl-1-piperazinecarboxylate

生成物 1

HCID 691415642,6-Difluoro-4-difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

実験手順

2,6-Difluoro-4-difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 2,6-difluoro-4-difluoromethoxybenzyl alcohol according to the method described for Example 54 to give the product as a, white solid (0.1406 g, 65% overall); νmax (nujol)/cm−1 3342, 1684, 1640, 1599, 1378, 1308, 1166, and 1089; δH (400 MHz, DMSO-d6) 9.69 (2H, br), 7.38 (1H, t, J 73 Hz), 7.15–7.10 (2H, m), 5.14 (2H, s), 4.24 (2H, m), 3.13 (2H, d, J 13 Hz), 3.05 (2H, dd, J 5.2 and 13 Hz), and 1.27 (6H, d, J 7.2 Hz).

後処理

  1. customto give the product as a, white solid (0.1406 g, 65% overall)

出典と根拠

ORDレコード
ord-b63c0ea28f5e4419963531ed084e00a7
出典データセット
uspto-grants-2006_04
特許番号
US07022707B2

関連ノート

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