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1-Iodopropane → (R)-2,6-Difluoro-4-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | (R)-4-Difluoromethoxybenzyl 2-ethylpiperazine-1-carboxylate fumarate | HCID 21021913 | — |
| 反応物 | 3,5-Difluoro-4-(hydroxymethyl)phenol | HCID 22219975 | — |
| 生成物 | (R)-2,6-Difluoro-4-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate | HCID 21021908 | — |
反応手順
(R)-2,6-Difluoro-4-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate was prepared from (R) 1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine, 1-iodopropane and 2,6-difluoro-4-hydroxybenzyl alcohol according to the methods described for Examples 54 and 96 to give the product as a white solid (19.2%); melting point 193.9–194.0° C.; NMR δH (400 MHz, DMSO-d6) 0.958(3H, t, J 7.5 Hz), 1.140(3H, d, J 7.0 Hz), 1.715(2H, m), 2.817(2H, m), 2.982(2H, m), 3.687(2H, m), 4.097(1H, bs), 5.027(2H, q, J 11.0 Hz), 6.573(2H, s) and 6.773(2H, d, J 10.0 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07022707B2 |
| 出典データセット | uspto-grants-2006_04 |
| ORD ID | ord-8de8cbb695424bc78d4ab623c845748a |
| 出典メモ | uspto-grants-2006_04 |