4-(Chloromethyl)-2-methyl-1,3-thiazole → 2,6-Difluoro-4-[(2-methyl-4-thiazolyl)methoxy]benzenemethanol

HRID 1794148ノート

反応式

HRID 1794148 の反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9].Cl[CH2:13][C:14]1[N:15]=[C:16]([CH3:19])[S:17][CH:18]=1>>[F:1][C:2]1[CH:3]=[C:4]([O:11][CH2:13][C:14]2[N:15]=[C:16]([CH3:19])[S:17][CH:18]=2)[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]

参加物

3

反応物 2

HCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazoleHCID 222199753,5-Difluoro-4-(hydroxymethyl)phenol

生成物 1

HCID 222199552,6-Difluoro-4-[(2-methyl-4-thiazolyl)methoxy]benzenemethanol収率 73%

実験手順

This compound was prepared from 3,5-difluoro-4-hydroxymethyl-phenol and 4-chlormethyl-2-methylthiazol according to the procedure described in Example 179 to give the product as a colorless oil (369 mg, 73%); MS (ISP): 272.3 (M+H)+.

出典と根拠

ORDレコード
ord-d1e7f5499b5c414ebae3b44093005352
出典データセット
uspto-grants-2006_04
特許番号
US07022707B2

反応ノート

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