Potassium Carbonate → [(6-Bromopyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795137ノート

反応式

HRID 1795137 の反応式
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[Br:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25]Br)=[CH:21][CH:20]=1>CS(C)=O>[Br:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 64246602-Bromo-5-bromomethylpyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

生成物 1

HCID 22185751[(6-Bromopyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile収率 30.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

By using (3,3,3-trifluoropropyl)malononitrile (3.6 g), dimethylsulfoxide (20 ml), potassium carbonate (3.0 g) and 6-bromo-3-(bromomethyl)pyridine (5.5 g) according to the similar method described in Production Example 4 was obtained 2.2 g of 2-((6-bromo-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (10)).

出典と根拠

ORDレコード
ord-102dbef8c4284dce9d47afab3c3d4b41
出典データセット
uspto-grants-2006_04
特許番号
US07026340B2

反応ノート

読み込み中…