Potassium Carbonate → [(6-Bromopyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795139ノート

反応式

HRID 1795139 の反応式
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[Br:18][C:19]1[N:24]=[C:23]([CH2:25]Br)[CH:22]=[CH:21][CH:20]=1>CN(C)C=O>[Br:18][C:19]1[N:24]=[C:23]([CH2:25][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])[CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 129547962-Bromo-6-(bromomethyl)pyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

生成物 1

HCID 22185765[(6-Bromopyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile収率 69.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

By using (3,3,3-trifluoropropyl)malononitrile (540 mg), N,N-dimethylformamide (4 ml), potassium carbonate (400 mg) and 6-bromo-2-(bromomethyl)pyridine (590 mg) according to the similar method described in Production Example 4 was obtained 541 mg of 2-((6-bromo-2-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (14)).

出典と根拠

ORDレコード
ord-7737d0aca69741869a89fb73a66e5e09
出典データセット
uspto-grants-2006_04
特許番号
US07026340B2

反応ノート

読み込み中…