Bromine → 2-Bromo-1-(4-octylphenyl)ethanone

HRID 1795497ノート

反応式

HRID 1795497 の反応式
[CH2:1]([C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[BrH:18].C(O)(=O)C.BrBr>C(O)(=O)C>[Br:18][CH2:16][C:15]([C:12]1[CH:11]=[CH:10][C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[CH:14][CH:13]=1)=[O:17]

参加物

5

反応物 3

HCID 24408BromineHCID 66344Ethanone, 1-(4-octylphenyl)-HCID 21893785Acetic Acid Mixture with Hydrobromic Acid

生成物 1

HCID 113013752-Bromo-1-(4-octylphenyl)ethanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
30 °C

実験手順

To a solution of 4′-octylacetophenone (18′) (23.9 g) in acetic acid (100 ml) is added hydrogen bromide-acetic acid solution (25%, 34 ml) under ice-cooling, which is followed by dropwise addition of bromine (5.3 ml). The mixture is heated to 30° C. and stirred for 3 hr. The solvent is distilled away and the mixture is purified by silica gel column chromatography to give 2-bromo-4′-octylacetophenone as colorless crystals.

後処理

  1. temperaturecooling
  2. distillationThe solvent is distilled away
  3. customthe mixture is purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-e06e6e4d0f4d4d0d9bc07229d45cc8ee
出典データセット
uspto-grants-2006_04
特許番号
US07026522B2

反応ノート

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