HCID 12088903、化合物 → HCID 22218198、化合物

反応式

[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:15])([CH3:14])[CH2:8][CH2:9][C:10]2=O)=[CH:5][C:4]=1[CH3:16].[C:17]([Mg]Cl)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([C:10]1[C:11]2[C:6](=[CH:5][C:4]([CH3:16])=[C:3]([O:2][CH3:1])[CH:12]=2)[C:7]([CH3:15])([CH3:14])[CH2:8][CH:9]=1)([CH3:20])([CH3:19])[CH3:18]

参加物

反応物 2

HCID 12088903HCID 12088903、化合物2 回

HCID 178418310HCID 178418310、化合物

生成物 1

HCID 22218198HCID 22218198、化合物収率 36%

実験手順

Following General Procedure A, 7-methoxy-4,4,6-trimethyl-3,4-dihydro-2H-naphthalen-1-one (Compound 6, 1.5 g, 6.9 mmol) was reacted with a solution of 2 M tert-butylmagnesium chloride (12 mL, 23 mmol), and the crude product was purified by flash column (hexane:ethyl acetate=4:1) to give 0.63 g (36%) of the title product as a clear oil.

後処理

customthe crude product was purified by flash column (hexane:ethyl acetate=4:1)

出典と根拠

ORDレコード: ord-f708e715a0334f35a54746b9b797d964
出典データセット: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07026487B2

反応ノート

読み込み中…

参加物