2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-6-methylbenzenesulfonamide

HRID 1795930

反応式

HRID 1795930 の反応式
Br.[NH2:2][C:3]1[S:4][C:5]2[C:11](=[O:12])[CH2:10][C:9]([CH3:14])([CH3:13])[CH2:8][C:6]=2[N:7]=1.[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[S:24](Cl)(=[O:26])=[O:25]>>[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[S:24]([NH:2][C:3]1[S:4][C:5]2[C:11](=[O:12])[CH2:10][C:9]([CH3:14])([CH3:13])[CH2:8][C:6]=2[N:7]=1)(=[O:26])=[O:25]

参加物

3

反応物 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 122532892-Amino-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrobromide

生成物 1

HCID 98449732,4-Dichloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-6-methylbenzenesulfonamide

実験手順

The title compound was prepared from 2-amino-5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one hydrobromide and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (26 mg) with purity >90%: MS (pos) m/z 419.1, 421.1; HRMS m/z 417.9979 (calc. of monoisotopic mass for C16H16Cl2N2O3S2 gives 417.9979).

出典と根拠

ORDレコード
ord-43173c4a26b444c69d7f0de799aa0fda
出典データセット
uspto-grants-2006_04
特許番号
US07030135B2

関連ノート

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